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These amenable properties demonstrated for the small molecules led us to conduct a proof-of-concept in vivo study in diet-induced obese mice to test the hypothesis that the most potent inhibitor when administered systemically, would reverse obesity by causing substantial loss of body weight and adiposity without causing any observable adverse effects

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Post-orthopedic-surgery patients in the soft-tissue phase: typically four to twelve weeks out of surgery, with surgeon sign-off and a clear remodeling window ahead